Vascularized Composite Allo- and auto- transplant (VCA) research developing translational models for reconstructive transplantation.
Donor Tissue Specific Immunomodulation research to obviate the need for chronic toxic immunosuppression in service members who are candidates for VCA.
Clinical Vascularized Composite Allo- and Auto- transplantation reconstructing and re- functionalizing service members with upper extremity amputations through Auto- and Allo-transplantation.
Regenerative Medicine combining biologic scaffolds, adult stem cells and growth factors to produce high quality composite replacement tissues, improve range of motion, scar compliance, and aesthetics while improving scar quality through safe and effective modalities
Publications
Gorantla VS, Davis MR. Vascularized Composite Allograft Preservation: Ubi Sumus? Journal Transplantation.
Kostereva NV, Wang Y, Fletcher DR, Unadkat JV, Schnider JT, Komatsu C, Yang Y, Stolz DB, Davis MR, Plock JA, Gorantla VS. (2016) IGF-1 and Chondroitinase ABC Augment Nerve
Regeneration after Vascularized Composite Limb Allotransplantation. PLoS ONE 11(6): e0156149. doi:10.1371/journal.pone.0156149
S Lawson, L Wang, CA Fries, MR Davis, VS Gorantla. Lower Extremity Allotransplantation in: Lower Extremity Gait Systems (LEGS) Program / Full Strides. Springer Publishing. 2016. In press.
S Lawson, L Wang, CA Fries, MR Davis, VS Gorantla. Development of a Clinical Vascularized Composite Allotransplantation (VCA) Program: Requirements and Recommendations. Karger Publishing. 2016.
Fries, CA, Villamaria, CY, Spencer, JR, Rickard, RF, Gorantla, VS, Davis, MR. A Porcine Orthotopic Forelimb Vascularized Composite Allotransplantation Model: Technical Considerations and Translational Implications. Plastic and Reconstructive Surgery. Volume 138(2), September 2016, p 461e-417e.
Fries, CA, Villamaria, CY, Spencer, JR, Rasmussen, TE and Davis, MR (2016), C1 esterase inhibitor ameliorates ischemia reperfusion injury in a swine musculocutaneous flap model. Microsurgery. doi:10.1002/micr.30053. Early View.
Cannon J, Davis M, Elster, E, et al Dismounted complex blast injuries: a comprehensive review of the modern combat experience. Journal of the American College of Surgeons. 2016. Pending Publication.
Fries CA, Villamaria CY, Spencer JR, Rasmussen TE, Davis MR. Hyperbaric warm ex vivo perfusion preserves tissue composites beyond normal limits of cold ischemia. 2015. JTransplatation. Submitted.
Villamaria CY, Spencer JR, Fries AC, Davis MR, Roth M. Hydrogen Sulfide Mitigates Reperfusion Injury in Porcine Model of Vascularized Composite Autotransplantation. Ann Plast Surg 2014;72.
Villamaria CY, Rasmussen TE, Spencer JR, Patel S, Davis MR. Microvascular porcine model for the optimization of vascularized composite tissue transplantation. J Surg Res. 2012; 178(1):452-9
Villamaria C,Rasmussen T, Spencer J, Davis M. (PVSS2). Microvascular Porcine Model for the Optimization of Composite Tissue AutoTransplantation, J. Vasc. Surg. 2012; 55(6):Suppl 4S-5S.
Xing G. Cheng,, Robert G. Hale, Michael R. Davis, Hyun-Wook Kang, Sang J. Lee. 3D Printed Biomaterials for Maxillofacial Tissue Engineering and Reconstruction – A Review Open Journal of Biomedical Materials Research (2014) 33-39
